Tellimagrandin II

Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases[1][2][3][4].

Product Specifications

CAS Number

[81571-72-4]

Product Name Alternative

Eugeniin

UNSPSC

12352005

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tellimagrandin-ii.html

Purity

98.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC[C@H]1O[C@@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[C@H](OC(C3=CC(O)=C(O)C(O)=C3)=O)[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H]1OC(C5=CC(O)=C(O)C(O)=C56)=O)C7=C6C(O)=C(O)C(O)=C7

Molecular Formula

C41H30O26

Molecular Weight

938.66

References & Citations

[1]Ruth Niemetz, et al. Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves. Phytochemistry. 2003 Feb;62 (3) :301-6.|[2]Yu-Wei Chang, et al. Tellimagrandin II, A Type of Plant Polyphenol Extracted from Trapa bispinosa Inhibits Antibiotic Resistance of Drug-Resistant Staphylococcus aureus. Int J Mol Sci. 2019 Nov 18;20 (22) :5790.|[3]Lin CY, et al. Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages. Life (Basel) . 2021 Apr 30;11 (5) :411.|[4]Chen LG, et al. Hydrolysable Tannins Exhibit Acetylcholinesterase Inhibitory and Anti-Glycation Activities In Vitro and Learning and Memory Function Improvements in Scopolamine-Induced Amnesiac Mice. Biomedicines. 2021 Aug 23;9 (8) :1066.