Tolnaftate-d7

Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].

Product Specifications

CAS Number

[1329835-64-4]

UNSPSC

12352005

Target

Fungal; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

CN(C1=CC(C)=CC=C1)C(OC2=C([2H])C3=C(C([2H])=C([2H])C([2H])=C3[2H])C([2H])=C2[2H])=S

Molecular Formula

C19H10D7NOS

Molecular Weight

314.45

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ryder, N.S., I. Frank, and M.C. Dupont, Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother, 1986. 29 (5) : p. 858-60.|[3]Georgopapadakou, N.H. and A. Bertasso, Effects of squalene epoxidase inhibitors on Candida albicans. Antimicrob Agents Chemother, 1992. 36 (8) : p. 1779-81.