Pyridoxal Phosphate-d3
Pyridoxal Phosphate-d3 is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) [1][2].
Product Specifications
CAS Number
[1354560-58-9]
Product Name Alternative
Pyridoxal 5'-phosphate-d3
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β; Endogenous Metabolite; ERK
Type
Isotope-Labeled Compounds
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Purity
98.01
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming)
Smiles
O=CC1=C(O)C(C([2H])([2H])[2H])=NC=C1COP(O)(O)=O
Molecular Formula
C8H7D3NO6P
Molecular Weight
250.16
Precautions
H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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