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Pyridoxal Phosphate-d3

Pyridoxal Phosphate-d3 is the deuterium labeled Pyridoxal 5'-phosphate. Pyridoxal 5'-phosphate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′-phosphate (PMP) [1][2].

Product Specifications

CAS Number

[1354560-58-9]

Product Name Alternative

Pyridoxal 5'-phosphate-d3

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β; Endogenous Metabolite; ERK

Type

Isotope-Labeled Compounds

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Purity

98.01

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming)

Smiles

O=CC1=C(O)C(C([2H])([2H])[2H])=NC=C1COP(O)(O)=O

Molecular Formula

C8H7D3NO6P

Molecular Weight

250.16

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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