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Tolmetin (sodium dihydrate) (Standard)

Tolmetin (sodium dihydrate) (Standard) is the analytical standard of Tolmetin (sodium dihydrate) . This product is intended for research and analytical applications. Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID) [1][2].

Product Specifications

CAS Number

64490-92-2

UNSPSC

12352005

Target

COX; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tolmetin-sodium-dihydrate-standard.html

Smiles

O=C(O[Na])CC1=CC=C(C(C2=CC=C(C)C=C2)=O)N1C.O.O

Molecular Formula

C15H18NNaO5

Molecular Weight

315.30

References & Citations

[1]Morini G, et al. Morphological features of rat gastric mucosa after acute and chronic treatment with amtolmetin guacyl: comparison with non-selective and COX-2-selective NSAIDs. Digestion. 2003;68 (2-3) :124-32. Epub 2003 Nov 7.|[2]Etcheverry SB, et al. Three new vanadyl (IV) complexes with non-steroidal anti-inflammatory drugs (Ibuprofen, Naproxen and Tolmetin) . Bioactivity on osteoblast-like cells in culture. J Inorg Biochem. 2002 Jan 1;88 (1) :94-100.|[3]Dairam A, et al. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons. Metab Brain Dis. 2006 Sep;21 (2-3) :221-33.|[4]T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96 (13) :7563-8.|[5]DADAŞ, Yakup, et al. Synthesis and anticancer activity of some novel tolmetin thiosemicarbazides. Marmara Pharmaceutical Journal 19 (3) • April 2015

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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