Isoalantolactone
Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.
Product Specifications
CAS Number
[470-17-7]
Product Name Alternative
(+) -Isoalantolactone; Isohelenin
UNSPSC
12352005
Hazard Statement
H317
Target
Apoptosis; Autophagy; Bacterial; Endogenous Metabolite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Isoalantolactone.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[C@@](C[C@@]1(C)CCC2)([H])[C@]3([H])C[C@@]1([H])C2=C)C3=C
Molecular Formula
C15H20O2
Molecular Weight
232.32
Precautions
H317
References & Citations
[1]Lawrence NJ, et al. Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. Bioorg Med Chem Lett. 2001 Feb 12;11 (3) :429-31.|[2]Khan M, et al. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. Int J Biol Sci. 2012;8 (4) :533-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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