Hypusine (dihydrochloride)
Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A) . Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety[1][2].
Product Specifications
CAS Number
[82310-93-8]
UNSPSC
12352211
Target
Amino Acid Derivatives
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hypusine-dihydrochloride.html
Smiles
O=C([C@H](CCCCNC[C@@H](CCN)O)N)O.Cl.Cl
Molecular Formula
C10H25Cl2N3O3
Molecular Weight
306.23
References & Citations
[1]Park MH, et al. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. J Biol Chem. 2018 Nov 30;293 (48) :18710-18718.|[2]Beninati S, et al. Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells. FEBS Lett. 1998 Oct 16;437 (1-2) :34-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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