Hypusine (dihydrochloride)

Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A) . Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety[1][2].

Product Specifications

CAS Number

[82310-93-8]

UNSPSC

12352211

Target

Amino Acid Derivatives

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/hypusine-dihydrochloride.html

Smiles

O=C([C@H](CCCCNC[C@@H](CCN)O)N)O.Cl.Cl

Molecular Formula

C10H25Cl2N3O3

Molecular Weight

306.23

References & Citations

[1]Park MH, et al. Hypusine, a polyamine-derived amino acid critical for eukaryotic translation. J Biol Chem. 2018 Nov 30;293 (48) :18710-18718.|[2]Beninati S, et al. Tissue transglutaminase expression affects hypusine metabolism in BALB/c 3T3 cells. FEBS Lett. 1998 Oct 16;437 (1-2) :34-8.