CuATSM

CuATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. CuATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities[1][2].

Product Specifications

CAS Number

68341-09-3

UNSPSC

12352300

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cuatsm.html

Purity

99.13

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC1=[N]2[N-]C(NC)=[S][Cu+2]32[S]=C(NC)[N-][N]3=C1C

Molecular Formula

C8H14CuN6S2

Molecular Weight

321.91

References & Citations

[1]Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis (Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143 (45) :19043-19057.|[2]Shi X, et al., Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. Neurosci Res. 2021 May;166:55-61.