Linopirdine dihydrochloride

KCNQ Channel Blocker

Product Specifications

Background

Linopirdine increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels (1-3). Linopirdine is a state-dependent blocker favoring activated single subunits of the channel(4).

CAS Number

113168-57-3

Product Name Alternative

1-Phenyl-3,3-bis (pyridine-4-ylmethyl) indolin-2-one, dihydrochloride; DuP996

UNSPSC

41116105

Type

Blocker

Source

Synthetic

Field of Research

Neuroscience | Neurotransmission | Ion Channels | Potassium Channels | Voltage-Gated Potassium Channels

Purity

>98% (HPLC) ; NMR (Conforms)

Weight

0.005

Format

Off-white powder

Solubility

May be dissolved in DMSO (25 mg/ml): or water (25 mg/ml)

Molecular Formula

C26H23Cl2N3O

Molecular Weight

464.4

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. D Kristufeck et al. J. Neurochem. 1999 72:2083 2. HS Wang et al. Science 1998 282:1890 3. DJ Fontana et al. Pharmacol. Biochem. Behav. 1994 49:1075 4. DL Greene et al. J. Pharmacol. Exp. Ther. 2017 362:177