2-Ketoglutaric acid (Sodium)

2-Ketoglutaric acid Sodium (Alpha-Ketoglutaric acid Sodium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid Sodium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid Sodium is a reversible inhibitor of tyrosinase (IC50=15 mM) [1][2].

Product Specifications

CAS Number

[22202-68-2]

Product Name Alternative

Alpha-Ketoglutaric acid (Sodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Tyrosinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alpha-ketoglutaric-acid-sodium-salt.html

Purity

98.0

Solubility

DMSO : 5.88 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 200 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C(CCC(O)=O)=O

Molecular Formula

C5H5NaO5

Molecular Weight

168.08

Precautions

H302, H315, H319, H335

References & Citations

[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.