Ketanserinol

Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562) . Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries[1].

Product Specifications

CAS Number

[76330-73-9]

Product Name Alternative

R 46742

UNSPSC

12352005

Target

5-HT Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ketanserinol.html

Purity

98.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=C(C2=O)C=CC=C1)N2CCN3CCC(CC3)C(O)C4=CC=C(C=C4)F

Molecular Formula

C22H24FN3O3

Molecular Weight

397.44

References & Citations

[1]Frenken M, et al. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326 (4) :334-9.