Ketanserinol
Ketanserinol (R 46742) is a metabolite of Ketanserin (HY-10562) . Ketanserinol is a competitive antagonist of the effects of 5-HT (HY-B1473A) in both arteries. The KB values are 6.5 for large coronary arteries and 6.4 for pulmonary arteries[1].
Product Specifications
CAS Number
[76330-73-9]
Product Name Alternative
R 46742
UNSPSC
12352005
Target
5-HT Receptor; Drug Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ketanserinol.html
Purity
98.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C2=O)C=CC=C1)N2CCN3CCC(CC3)C(O)C4=CC=C(C=C4)F
Molecular Formula
C22H24FN3O3
Molecular Weight
397.44
References & Citations
[1]Frenken M, et al. Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. Naunyn Schmiedebergs Arch Pharmacol. 1984 Jul;326 (4) :334-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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