TDI-11861
TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 , with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology[1][2].
Product Specifications
CAS Number
2857049-72-8
UNSPSC
12352005
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tdi-11861.html
Concentration
10mM
Purity
99.35
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=NC(C2=NN(C=C2CC3=C(C=CC=C3)OCCN4CCOC[C@H]4CO)C(F)F)=CC(Cl)=N1
Molecular Formula
C22H25ClF2N6O3
Molecular Weight
494.92
References & Citations
[1]Miller M, et al. Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J Med Chem. 2022 Nov 8. |[2]Kim J, et al. Advances in Male Contraception: When Will the Novel Male Contraception be Available? World J Mens Health. 2024 Jul;42 (3) :487-501.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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