Mn (III) Protoporphyrin IX chloride

Mn (III) protoporphyrin IX chloride is a metalloporphyrin. It induces mRNA expression of the genes encoding δ-aminolevulinate synthase and heme oxygenase (HO), enzymes that catalyze the rate-limiting steps of heme biosynthesis and degradation, respectively, in chick embryo liver cells when used at a concentration of 10 μM. Mn (III) protoporphyrin IX chloride-containing nanobialys have been used in magnetic resonance imaging (MRI) of fibrin clots in vitro. It has also been used in the synthesis of Mn (III) protoporphyrin IX-6 (7) -glycyl-glycyl-L-histidine methyl ester (MnGGH), a metalloporphyrin conjugate with microperoxidase activity.

Product Specifications

CAS Number

[120389-54-0]

Product Name Alternative

Manganese (III) Protoporphyrin IX Chloride

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Heme Oxygenase (HO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mn-iii-protoporphyrin-ix-chloride.html

Purity

Smiles

O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC([O-])=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Mn+3]3([N-]78)([N-]54)[Cl-])[O-].[H+].[H+]

Molecular Formula

C34H32ClMnN4O4

Molecular Weight

651.03

Precautions

H302, H315, H319, H335

References & Citations

[1]Cable, et al. Differential effects of metalloporphyrins on messenger RNA levels of δ-aminolevulinate synthase and heme oxygenase. Studies in cultured chick embryo liver cells. J. Clin. Invest. 94 (2), 649-654 (1994) .