Shikonin (Standard)
Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7].
Product Specifications
CAS Number
517-89-5
Product Name Alternative
C.I. 75535 (Standard) ; Isoarnebin 4 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AIM2; Chloride Channel; HIV; NF-κB; Pyruvate Kinase; Reference Standards; TNF Receptor
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shikonin-standard.html
Purity
98.54
Smiles
O=C1C([C@H](O)C/C=C(C)/C)=CC(C2=C1C(O)=CC=C2O)=O
Molecular Formula
C16H16O5
Molecular Weight
288.30
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD1 (CD1D) (NM_001766) Human Over-expression Lysate
