NSC3852
NSC3852 exhibits anti-proliferative activity against cancer cell MCF-7. NSC3852 promotes the ROS generation, DNA damage, and apoptosis in MCF-7. NSC3852 exhibits anti-tumor against leukemia in mouse model[1]
Product Specifications
CAS Number
[3565-26-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc3852.html
Concentration
10mM
Purity
95.0
Solubility
DMSO : 35 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C2N=CC=CC2=C(N=O)C=C1
Molecular Formula
C9H6N2O2
Molecular Weight
174.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Martirosyan A, et al., Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J Pharmacol Exp Ther. 2006 May;317 (2) :546-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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