TASP0415914
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC50 of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC50 of 294 nM. TASP0415914 can be used for inflammatory diseases research[1].
Product Specifications
CAS Number
1292300-75-4
UNSPSC
12352005
Target
Akt; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tasp0415914.html
Purity
99.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(NC1=NC(C)=C(C2=NC(N3CC(O)CCC3)=NO2)S1)=O
Molecular Formula
C13H17N5O3S
Molecular Weight
323.37
References & Citations
[1]Yusuke Oka, et al. Discovery of N-{5-[3- (3-hydroxypiperidin-1-yl) -1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem. 2013 Dec 15;21 (24) :7578-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ
Available Sizes
Frequently Asked Questions
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