AN-3485 (hydrochloride)
AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity[1][2].
Product Specifications
CAS Number
1213786-72-1
UNSPSC
12352005
Target
Interleukin Related; NF-κB; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/an-3485-hydrochloride.html
Smiles
OB1OCC2=CC=C(C=C12)OC3=CC=C(C=C3Cl)CN.[H]Cl
Molecular Formula
C14H14BCl2NO3
Molecular Weight
325.98
References & Citations
[1]Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344 (2) :436-46.|[2]Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6
Frequently Asked Questions
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