Kanosamine

Kanosamine (3-Amino-3-deoxyglucose) is an antibiotic against Saccharomyces cerevisiae and human pathogenic fungi Candida albicans. Kanosamine exhibits antifungal activity through inhibition of cell wall synthesis and inhibition of GlcN-6-P synthase with phosphorylated kanosamine-6-phosphate in cytoplasma[1][2].

Product Specifications

CAS Number

[576-44-3]

Product Name Alternative

3-Amino-3-deoxyglucose

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kanosamine.html

Solubility

10 mM in DMSO

Smiles

O=C[C@H](O)[C@H]([C@H](O)[C@H](O)CO)N

Molecular Formula

C6H13NO5

Molecular Weight

179.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Janiak AM, et al., Mechanism of antifungal action of kanosamine. Med Mycol. 2001 Oct;39 (5) :401-8.|[2]Iwai Y, Tet al., Studies on bacterial cell wall inhibitors. III. 3-amino-3-deoxy-D-glucose, an inhibitor of bacterial cell wall synthesis. Biochim Biophys Acta. 1977 Jun 23;498 (1) :223-8.