DNMT1-IN-4
DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 2.5 µM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation[1].
Product Specifications
CAS Number
889797-65-3
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dnmt1-in-4.html
Smiles
OC(CNCCC1=CNC2=C1C=CC=C2)CN3C4=C(C=C(C=C4)Cl)C5=C3C=CC(Cl)=C5
Molecular Formula
C25H23Cl2N3O
Molecular Weight
452.38
References & Citations
[1]Chen S, ET AL. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57 (21) :9028-41.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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