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DNMT1-IN-4

DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 2.5 µM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation[1].

Product Specifications

CAS Number

889797-65-3

UNSPSC

12352005

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dnmt1-in-4.html

Smiles

OC(CNCCC1=CNC2=C1C=CC=C2)CN3C4=C(C=C(C=C4)Cl)C5=C3C=CC(Cl)=C5

Molecular Formula

C25H23Cl2N3O

Molecular Weight

452.38

References & Citations

[1]Chen S, ET AL. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57 (21) :9028-41.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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