Human Kininogen (HMW) Deficient Serum

<strong>Human Kininogen (HMW) Deficient Serum</strong>_x000D_ <strong>Catalog number:</strong> B2015412_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mL_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Serum_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Kininogen, High Molecular Weight Kininogen, Alpha-2-thiol Proteinase Inhibitor, HMWK, Fitzgerald Factor, Williams-Fitzgerald-Flaujeac Factor, BDK, BK, Bradykinin, Ile-Ser-Bradykinin, Lysyl-Bradykinin, Kallidin I, Kallidin II, Kininogen-1, KNG, KNG1, Low Molecular Weight Growth-promoting Factor, T-Kinin_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Girolami A, Scarparo P, Candeo N, Lombardi AM. Congenital prekallikrein deficiency Expert Rev Hematol. 2010 Dec;3(6):685-95._x000D_ 2: Donaldson VH, Kleniewski J, Saito H, Sayed JK. Prekallikrein deficiency in a kindred with kininogen deficiency and Fitzgerald trait clotting defect. Evidence that high molecular weight kininogen and prekallikrein exist as a complex in normal human plasma J Clin Invest. 1977 Sep;60(3):571-83._x000D_ 3: Banerji A, Busse P, Shennak M, Lumry W, Davis-Lorton M, Wedner HJ, Jacobs J, Baker J, Bernstein JA, Lockey R, Li HH, Craig T, Cicardi M, Riedl M, Al-Ghazawi A, Soo C, Iarrobino R, Sexton DJ, TenHoor C, Kenniston JA, Faucette R, Still JG, Kushner H, Mensah R, Stevens C, Biedenkapp JC, Chyung Y, Adelman B. Inhibiting Plasma Kallikrein for Hereditary Angioedema Prophylaxis N Engl J Med. 2017 Feb 23;376(8):717-728._x000D_ 4: Kleniewski J, Donaldson VH, Wagner CJ. Some molecular and functional changes in high molecular weight kininogen induced by plasmin and trypsin Thromb Res. 1982 Mar 1;25(5):387-99._x000D_ 5: Cicardi M, Bergamaschini L, Cugno M, Beretta A, Zingale LC, Colombo M, Agostoni A. Pathogenetic and clinical aspects of C1 inhibitor deficiency Immunobiology. 1998 Aug;199(2):366-76._x000D_ 6: Márkus B, Veszeli N, Temesszentandrási G, Farkas H, Kalabay L. Serum fetuin-A, tumor necrosis factor alpha and C-reactive protein concentrations in patients with hereditary angioedema with C1-inhibitor deficiency Orphanet J Rare Dis. 2019 Mar 18;14(1):67._x000D_ 7: Lacombe MJ, Miller DR, Wuepper KD. Proceedings: Flaujeac trait: deficiency of human HMW kininogen Thromb Diath Haemorrh. 1975 Sep 30;34(1):353._x000D_ 8: Shariat-Madar Z, Mahdi F, Schmaier AH. Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator J Biol Chem. 2002 May 17;277(20):17962-9._x000D_ 9: Ray TL, Wuepper KD. Activation of the alternative (properdin) pathway of complement by Candida albicans and related species J Invest Dermatol. 1976 Dec;67(6):700-3._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/16893067">10: Ghebrehiwet B, CebadaMora C, Tantral L, Jesty J, Peerschke EI. gC1qR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation Adv Exp Med Biol. 2006;586:95-105. </a>_x000D_ _x000D_ <strong>Products Related to Human Kininogen (HMW) Deficient Serum can be found at</strong> <a href="https://moleculardepot.com/product-category/Biofluids/"> Biofluids</a>