CYP51-IN-20
CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyp51-in-20.html
Smiles
O=C(N1CCC(N2N=CC(C3=NOC(N)=C3C(NCC4=CC=CC=C4)=O)=C2)CC1)OC(C)(C)C
Molecular Formula
C24H30N6O4
Molecular Weight
466.53
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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