Amyloid-Forming peptide GNNQQNY
Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)
Product Specifications
CAS Number
[339091-39-3]
UNSPSC
12352209
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amyloid-forming-peptide-gnnqqny.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC(CN)=O)=O)=O)=O)=O)=O
Molecular Formula
C33H48N12O14
Molecular Weight
836.81
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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