CaMKIIα-IN-1
CaMKIIα-IN-1 (Compound 4d) is an orally active Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a KD of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability[1].
Product Specifications
CAS Number
3031484-08-6
UNSPSC
12352005
Target
CaMK
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/camkiiα-in-1.html
Concentration
10mM
Purity
98.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=CC(O)=CC=C1OC2=CC=CC=C2Cl)O
Molecular Formula
C14H11ClO4
Molecular Weight
278.69
References & Citations
[1]Tian Y, et al. Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain. J Med Chem. 2022 May 12;65 (9) :6656-6676.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II
Available Sizes
Frequently Asked Questions
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