CaMKIIα-IN-1

CaMKIIα-IN-1 (Compound 4d) is an orally active Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) inhibitor with a KD of 219 nM for CaMKIIα WT hub. CaMKIIα-IN-1 has good metabolic stability[1].

Product Specifications

CAS Number

[3031484-08-6]

UNSPSC

12352005

Target

CaMK

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/camkiiα-in-1.html

Concentration

10mM

Purity

98.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CC1=CC(O)=CC=C1OC2=CC=CC=C2Cl)O

Molecular Formula

C14H11ClO4

Molecular Weight

278.69

References & Citations

[1]Tian Y, et al. Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain. J Med Chem. 2022 May 12;65 (9) :6656-6676.