N-Boc-cis-4-Hydroxy-D-proline
Product Specifications
UNSPSC Description
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the Synthesis of ADCs or PROTACs.
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-cis-4-hydroxy-d-proline.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)OC(N1[C@H](C[C@H](C1)O)C(O)=O)=O
Molecular Weight
231.248
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W002887/N-Boc-cis-4-Hydroxy-D-proline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W002887/N-Boc-cis-4-Hydroxy-D-proline-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
135042-12-5
Available Sizes
Curated Selection
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