MMAF intermediate 1
MMAF intermediate 1 is an intermediate in the synthesis of MMAF (HY-15579) . MMAF (Monomethylauristatin F) is a potent inhibitor of tubulin polymerization and the cytotoxic (ADC Cytotoxin) component of classic antibody drug conjugates (ADCs), such as Vorsetuzumab mafodotin and SGN-CD19A[1].
Product Specifications
CAS Number
[161485-82-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Payload
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmaf-intermediate-1.html
Purity
99.20
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)OC(C)(C)C
Molecular Formula
C24H36N2O6
Molecular Weight
448.55
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral human EPX shRNA (UAS) - Lentiviral human EPX shRNA (UAS) plasmid
SERPINA12 (Serpin A12, OL-64, Visceral Adipose Tissue-derived Serine Protease Inhibitor, Vaspin, Visceral Adipose-specific Serpin)