PKA-IN-1

PKA-IN-1 is a potent and selective cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor with an IC50 of 0.03 μM. PKA-IN-1 inhibits cAK in a fashion that is competitive with respect to ATP as substrate[1].

Product Specifications

CAS Number

[179985-52-5]

Product Name Alternative

CP-32396

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

PKA

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pka-in-1.html

Purity

99.82

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CC(NC1=NC(C)=C(C#N)C2=C1C=CC=C2)=O

Molecular Formula

C13H11N3O

Molecular Weight

225.25

Precautions

H302, H315, H319

References & Citations

[1]Z X Lu, et al. Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivative. Biol Chem Hoppe Seyler. 1996 Jun;377 (6) :373-8