JA310
JA310, a chemical probe, is a highly selective MST3 kinase inhibitor. JA310 has high cellular potency against MST3 with an EC50 value of 106 nM[1].
Product Specifications
CAS Number
[3022928-90-8]
UNSPSC
12352005
Target
Hippo (MST)
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ja310.html
Purity
99.83
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=CC(NC3=C4C(C=CC=C4)=NC(NCCCCCN1)=N3)=NN2
Molecular Formula
C17H19N7O
Molecular Weight
337.38
References & Citations
[1]Amrhein JA, et al. Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. J Med Chem. 2023 Dec 21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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