Psychosine
Product Specifications
UNSPSC Description
Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].
Target Antigen
PKC
Type
Reference compound
Related Pathways
Epigenetics;TGF-beta/Smad
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psychosine.html
Smiles
O[C@H]([C@H]([C@H]([C@@H](CO)O1)O)O)[C@@H]1OC[C@H](N)[C@H](O)/C=C/CCCCCCCCCCCCC
Molecular Weight
461.63
References & Citations
[1]M L Escolar, et al. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 Jul;121(3):271-278.|[2]Jacqueline A Hawkins-Salsbury,et al.Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. J Lipid Res.2013 Dec;54(12):3303-11.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136490/Psychosine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136490/Psychosine-SDS-MedChemExpress.pdf
CAS Number
2238-90-6
Available Sizes
Curated Selection
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