TCN238
TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC50 of 1 μM[1].
Product Specifications
CAS Number
125404-04-8
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TCN238.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=CC(/C=C/C2=CC=CC=C2)=N1
Molecular Formula
C12H11N3
Molecular Weight
197.24
Precautions
H315, H319, H320
References & Citations
[1]East SP, et al. An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20 (16) :4901-5.|[2]Pershina EV, et al. Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 2016 May 15;153:50-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4
Available Sizes
Frequently Asked Questions
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