TCN238

TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM) with an EC50 of 1 μM[1].

Product Specifications

CAS Number

[125404-04-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TCN238.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=CC(/C=C/C2=CC=CC=C2)=N1

Molecular Formula

C12H11N3

Molecular Weight

197.24

Precautions

H315, H319, H320

References & Citations

[1]East SP, et al. An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20 (16) :4901-5.|[2]Pershina EV, et al. Subacute activation of mGlu4 receptors causes the feedback inhibition of its gene expression in rat brain. Life Sci. 2016 May 15;153:50-4.