JAK1/2-IN-1
JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a) [1].
Product Specifications
CAS Number
[3023876-01-6]
UNSPSC
12352005
Target
Interleukin Related; JAK
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak1-2-in-1.html
Purity
98.36
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=C(N=C(NC2=CC(C(F)(F)F)=C3C(COB3O)=C2)N=C1)N[C@H]4[C@H](C#N)CCOC4
Molecular Formula
C19H19BF3N5O3
Molecular Weight
433.19
References & Citations
[1]Alan Long, et al. Boron containing pyrimidine compounds, compositions comprising them, methods and uses thereof. WO2023244775A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-13; IL-4; JAK1; JAK2
Available Sizes
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