Norleual
Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF) /c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities[1].
Product Specifications
CAS Number
334994-34-2
UNSPSC
12352209
Target
Angiotensin Receptor; c-Met/HGFR
Type
Peptides
Related Pathways
GPCR/G Protein; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/norleual.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@@H](NC[C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CCCC)=O)CC(C=C3)=CC=C3O)=O)CC4=CN=CN4
Molecular Formula
C41H58N8O7
Molecular Weight
774.95
References & Citations
[1]B J Yamamoto, et al. The angiotensin IV analog Nle-Tyr-Leu-psi- (CH2-NH2) 3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J Pharmacol Exp Ther. 2010 Apr;333 (1) :161-73.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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