SU-11752
SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy[1].
Product Specifications
CAS Number
688036-19-3
UNSPSC
12352005
Target
DNA-PK; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/su-11752.html
Smiles
O=C(CCC1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(NC4=CC=CC=C4)=O)=O)=C1CC)CC)O
Molecular Formula
C26H27N3O5S
Molecular Weight
493.57
References & Citations
[1]Ismail IH, et al., SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. Oncogene. 2004 Jan 29;23 (4) :873-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kγ
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1295203 1.0 µg DNA
MEX3D sgRNA CRISPR Lentivector (Human) (Target 2)
Sign In for Pricing
View Details