Human ACE2 / ACEH Protein, His Tag (MALS verified)
Human ACE2, His Tag (AC2-H52H4) is expressed from human 293 cells (HEK293) .
Product Specifications
Background
Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 85.5 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q9BYF1-1
Host
HEK293
Target
ACE2
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
95%
Bioactivity
Immobilized Human ACE2, His Tag (Cat. No. AC2-H52H4) at 2 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein RBD, Fc Tag (Cat. No. SPD-C5255) with a linear range of 0.1-0.8 ng/mL (QC tested).
Format
Liquid
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
85.5 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
10mg*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/AC2-H52H4.pdf
Species
Human
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