Calcium dobesilate

Calcium dobesilate is a vascular protector with oral activity that can clear hydroxyl free radicals, with an IC50 of 1.1 pM. Calcium dobesilate has antioxidant activity and helps to reduce oxidative stress and inflammation in the retinas of diabetic mice. Calcium dobesilate can be used to study chronic venous diseases, diabetic retinopathy, and the occurrence of hemorrhoids, among other conditions[1][2][3].

Product Specifications

CAS Number

[20123-80-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Calcium_dobesilate.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 150 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(C1=CC(O)=CC=C1O)([O-])=O.O=S(C2=CC(O)=CC=C2O)([O-])=O.[Ca+2]

Molecular Formula

C12H10CaO10S2

Molecular Weight

418.41

Precautions

H315, H319, H335

References & Citations

[1]J Brunet, et al. In vitro antioxidant properties of calcium dobesilate. Fundam Clin Pharmacol. 1998;12 (2) :205-12.|[2]GA Losa, et al. Prevention of Oxidation and Apoptosis in Human Peripheral Blood Mononuclear Cells Exposed to Calcium Dobesilate. Int J Angiol. 1999;8 (5) :11-15.|[3]Patricia Bogdanov, et al. Calcium dobesilate prevents the oxidative stress and inflammation induced by diabetes in the retina of db/db mice. J Diabetes Complications. 2017 Oct;31 (10) :1481-1490.