BAY-593
BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity[1].
Product Specifications
CAS Number
2413020-56-9
UNSPSC
12352005
Target
GGTase; YAP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-593.html
Purity
99.94
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(N1CCC2(CCNC[C@@]2([H])C3=CC=CC=C3OC)CC1)[C@@](OC)(C(F)(F)F)C4=CC=CC=C4
Molecular Formula
C26H31F3N2O3
Molecular Weight
476.53
References & Citations
[1]Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456 (24) 00087-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GGTase I
Available Sizes
Frequently Asked Questions
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