Anti-Mouse MAdCAM-1 Antibody (MECA-367)

Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse MAdCAM-1 IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes[1][2][3].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

L-Selectin

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-madcam-1-antibody-meca-367.html

Solubility

10 mM in DMSO

Smiles

[Anti-MouseMAdCAM-1Antibody(MECA-367)]

Molecular Weight

(150 kDa)

References & Citations

[1]Whyte A, et al. Pig lymphocytes utilise mouse MAdCAM-1 to enter fetal gut xenografts in SCID mice. Cell Immunol. 1997 Nov 25;182 (1) :38-44.|[2]Tyler CJ, et al. Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis. Mucosal Immunol. 2022 Jan;15 (1) :109-119.|[3]Phillips JM, et al. MAdCAM-1 is needed for diabetes development mediated by the T cell clone, BDC-2.5. Immunology. 2005 Dec;116 (4) :525-31.