T2AA
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].
Product Specifications
CAS Number
1380782-27-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t2aa.html
Concentration
10mM
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
IC(C=C(C[C@H](N)CO)C=C1I)=C1OC2=CC=C(O)C=C2
Molecular Formula
C15H15I2NO3
Molecular Weight
511.09
Precautions
H302, H315, H319
References & Citations
[1]Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289 (10) :7109-7120.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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