T2AA

T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase[1].

Product Specifications

CAS Number

1380782-27-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/t2aa.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

IC(C=C(C[C@H](N)CO)C=C1I)=C1OC2=CC=C(O)C=C2

Molecular Formula

C15H15I2NO3

Molecular Weight

511.09

Precautions

H302, H315, H319

References & Citations

[1]Akira Inoue, et al. A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J Biol Chem. 2014 Mar 7;289 (10) :7109-7120.