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Pimodivir (hydrochlorid hemihydrate)

Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit.

Product Specifications

CAS Number

1777721-70-6

Product Name Alternative

VX-787 (hydrochlorid hemihydrate)

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pimodivir-hydrochlorid-hemihydrate.html

Smiles

FC1=CN=C2NC=C(C3=NC=C(F)C(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=N3)C2=C1.Cl.O.[0.5]

Molecular Formula

C20H19F2N5O2.HCl.1/2H2O

Molecular Weight

444.87

References & Citations

[1]Smee DF, et al. Activities of JNJ63623872 and GS 4071 against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.|[2]Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31.|[3]Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1990-4.|[4]Byrn RA, et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59 (3) :1569-82.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 3

Frequently Asked Questions

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