Pimodivir (hydrochlorid hemihydrate)
Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit.
Product Specifications
CAS Number
1777721-70-6
Product Name Alternative
VX-787 (hydrochlorid hemihydrate)
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pimodivir-hydrochlorid-hemihydrate.html
Smiles
FC1=CN=C2NC=C(C3=NC=C(F)C(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=N3)C2=C1.Cl.O.[0.5]
Molecular Formula
C20H19F2N5O2.HCl.1/2H2O
Molecular Weight
444.87
References & Citations
[1]Smee DF, et al. Activities of JNJ63623872 and GS 4071 against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.|[2]Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31.|[3]Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1990-4.|[4]Byrn RA, et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59 (3) :1569-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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