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Nefiracetam (Standard)

Nefiracetam (Standard) is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research[1][2][3][4][5][6].

Product Specifications

CAS Number

77191-36-7

Product Name Alternative

DM9384 (Standard) ; DZL-221 (Standard)

UNSPSC

12352005

Target

Calcium Channel; GABA Receptor; iGluR; mGluR; nAChR; PKC; Reference Standards

Type

Reference Standards

Related Pathways

Epigenetics; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; TGF-beta/Smad

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nefiracetam-standard.html

Smiles

O=C(NC1=C(C)C=CC=C1C)CN2C(CCC2)=O

Molecular Formula

C14H18N2O2

Molecular Weight

246.30

References & Citations

[1]Nomura T, et al. Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action. Brain Res. 2000 Jul 7;870 (1-2) :157-62.|[2]Moriguchi S, et al. Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. J Neurochem. 2009 Jul;110 (1) :170-81.|[3]Nishizaki T, et al. A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam. Brain Res. 1999 May 1;826 (2) :281-8.|[4]Fukatsu T, et al. Effects of nefiracetam on spatial memory function and acetylcholine and GABA metabolism in microsphere-embolized rats. Eur J Pharmacol. 2002 Oct 18;453 (1) :59-67.|[5]Shiotani T, et al. Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res. 2000 Mar 24;859 (2) :255-61.|[6]Yoshii M, et al. Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384) . Behav Brain Res. 1997 Feb;83 (1-2) :185-8.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

L-type calcium channel; mGluR5; NMDA Receptor; N-type calcium channel

Available Sizes

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