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M4K2308

M4K2308 is a selective ether-linked inhibitor of ALK2 with an IC50 of 2 nM. M4K2308 exhibits exceptional selectivity for ALK2 over ALK5 (IC50 of 224 nM) . M4K2308 has the potential for the study of diffuse intrinsic pontine glioma (DIPG) research[1].

Product Specifications

CAS Number

3034840-18-8

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m4k2308.html

Smiles

COC(C=C1C2=C3C(C4=CC=C(N5CCNCC5)C=C4OCC3)=CN=C2)=C(C(OC)=C1)OC

Molecular Formula

C26H29N3O4

Molecular Weight

447.53

References & Citations

[1]Héctor González-Álvarez, et al. Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 28;67 (6) :4707-4725.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALK2; ALK5

Frequently Asked Questions

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