PROTAC 20S proteasome subunit β5 degrader 2
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for 20S proteasome subunit β5, with a DC50 of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC50 of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models[1]. (Pink: Ligand for target protein ; Blue: Ligand for E3 ligase (HY-103596) ; Black: Linker (HY-Y1760) )
Product Specifications
UNSPSC
12352005
Target
PROTACs; Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-20s-proteasome-subunit-β5-degrader-2.html
Smiles
O=C1CCC(C(N1)=O)N2C(C3=C(C(OCC(NC4=CC=C(C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@H](B6O[C@@]7(C)[C@@H](C[C@H]8CC7O6)C8(C)C)CC(C)C)=O)=O)=O)=CC=C3)C2=O)=O
Molecular Formula
C46H52BN5O10
Molecular Weight
845.74
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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