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Schaftoside

Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission[1].

Product Specifications

CAS Number

[51938-32-0]

UNSPSC

12352005

Target

Autophagy; Dynamin; Mitochondrial Metabolism; MyD88; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Autophagy; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/schaftoside.html

Purity

99.57

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C([C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C(O)=C3C(OC(C4=CC=C(O)C=C4)=CC3=O)=C1[C@H](OC[C@H](O)[C@@H]5O)[C@@H]5O

Molecular Formula

C26H28O14

Molecular Weight

564.49

References & Citations

[1]Zhou K, et al. Schaftoside ameliorates oxygen glucose deprivation-induced inflammation associated with the TLR4/Myd88/Drp1-related mitochondrial fission in BV2 microglia cells. J Pharmacol Sci. 2019 Jan;139 (1) :15-22.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

TLR4

Available Sizes

Curated Selection

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