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2-Bromo-4'-hydroxyacetophenone

2-Bromo-4'-hydroxyacetophenone is a PTP1B inhibitor with a Ki value of 42 μM. 2-Bromo-4'-hydroxyacetophenone is also an intermediate. 2-Bromo-4'-hydroxyacetophenone can be used in the synthesis of LXRα/β antagonists. 2-Bromo-4'-hydroxyacetophenone can be used in research on hematological diseases[1][2].

Product Specifications

CAS Number

2491-38-5

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Drug Intermediate; Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-bromo-4-hydroxyacetophenone.html

Purity

98.59

Solubility

DMSO : 200 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C(C(CBr)=O)C=C1

Molecular Formula

C8H7BrO2

Molecular Weight

215.05

Precautions

H302, H319

References & Citations

[1]Sidhu, Alban, et al. Toward Inhibitors of Protein Tyrosine Phosphatases for Cancer Treatment. Home / Current Enzyme Inhibition, Volume 4, Number 1.|[2]Nian S, et al. Discovery and Synthesis of a Novel Series of Liver X Receptor Antagonists. Chem Pharm Bull (Tokyo) . 2015;63 (8) :628-35.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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